GLP-1Pro
Glucagon-like peptide-1 (GLP-1) is a hormone that plays a key role in regulating blood glucose levels, digestion, metabolism, and appetite. Here are some of the ways GLP-1 works:
Blood glucose: GLP-1 is an incretin hormone that helps control blood glucose levels by stimulating insulin secretion and inhibiting glucagon secretion.
Appetite: GLP-1 acts as a satiety factor that reduces food intake and curbs cravings.
GLP-1 is released in the gut after eating, and it also affects the hypothalamus, which is the part of the brain that controls feelings of fullness.
Other effects: GLP-1 also helps with digestion and gastric emptying.
Synthesis: GLP-1 is produced in the gut and brain from the proglucagon gene.
Duration: GLP-1's effects are short-lived, lasting only 1–2 minutes in the circulatory system.
Degradation: GLP-1 is broken down by dipeptidyl peptidase IV (DPP-4), which reduces its effectiveness.
GLP-1 receptor agonists (GLP1-RA) can help with weight loss and may also promote bone formation.
What is the science behind GLP-1?
GLP-1 is released by the lining of the intestine in response to nutrient ingestion, particularly carbohydrates. It stimulates insulin secretion and, together with gastric inhibitory peptide, is one of the incretin hormones. It also slows gastric emptying.
GLP-1Pro
Diet Suggestions
A balanced diet rich in high fiber foods, healthy fats, and vegetables is beneficial when taking GLP-1 medications.
GLP-1 medications, or glucagon-like peptide-1 receptor agonists, treat type 2 diabetes when other medications haven’t sufficiently managed blood sugar levels.
Some GLP-1 agonists, like semaglutide and high dose liraglutide, are also FDA-approved for treating obesity.
These medications mimic the action of the hormone GLP-1 (glucagon-like peptide-1), which helps manage blood sugar levels by stimulating insulin release, reducing glucagon secretion, and slowing gastric emptying.
Following a balanced diet is important when taking GLP-1 medications because it can help improve the effectiveness of the medication in managing blood sugar levels and weight.
Some of the best foods to eat while on GLP-1 medications include:
- Eggs: Eggs are rich in protein and monounsaturated fats, which can trigger the release of GLP-1 and other hormones that help you feel full. They also contain many vitamins and minerals that can support overall health.
- Healthy fats: Healthy fats, such as those found in avocados, nuts, and olive oil, are rich in monounsaturated and polyunsaturated fats, which stimulate the release of GLP-1. They’re also important for brain health and hormone production.
- Whole grains: Whole grains, such as oats, brown rice, and quinoa, are high in fiber, which can help improve digestion and regulate blood sugar levels. They also provide a steady source of energy.
- Berries: Berries, such as blueberries and strawberries, are rich in antioxidants, which can help lower inflammation and improve overall health. They’re also low in sugar compared to other fruits.
- Legumes: Legumes, including beans, lentils, and chickpeas, are high in fiber and protein, which can help regulate blood sugar levels and promote digestive health.
- Vegetables: Vegetables like broccoli, carrots, and Brussels sprouts are not only low in calories and rich in nutrients but also high in fiber, potentially helping in the release of GLP-1 and regulating blood sugar levels.
- Leafy greens: Leafy greens, such as spinach, kale, and Swiss chard, are rich in fiber, vitamins, and minerals, which can help regulate blood sugar levels and improve your overall health.
- Proteins: Lean beef, chicken, turkey, Cornish hen and low fat fish.
Foods to avoid while on GLP-1
While taking GLP-1 medications, it’s advisable to avoid foods that can cause rapid spikes in blood sugar levels or lower the medication’s effectiveness, such as:
- sugary foods and beverages like juices, soda, and alcohol
- refined carbohydrates like white bread and pasta
- high fat foods
A study involving 72 participants with obesity revealed that those with high added sugar intake experienced the smallest increase in GLP-1 levels following glucose consumption.
GLP-1 medications can help reduce cravings for foods with fewer nutrients.
By promoting feelings of fullness, these medications can support dietary choices, as you’re less likely to feel hungry or crave high calorie, low nutrient foods. This can help with weight loss and improve overall health.
